5-Amino-1MQ

What it is

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a membrane-permeable small molecule, not a peptide, that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme expressed in adipose tissue and liver. It is supplied as a research reagent.

Where it has been studied

• NNMT inhibition and nicotinamide / NAD+ metabolism in cell and rodent models
• Adipocyte biology and diet-induced obesity models
• Muscle progenitor cell studies

Selected literature

• Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO miceDimet-Wiley A et al. · Sci Rep, 2022 · PMID 35013352
• Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cellsAkar S et al. · J Obstet Gynaecol, 2021 · PMID 33645410

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.