MOTS-c
What it is
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA gene. Discovered in 2015, it is studied as a mitochondrial signal that translocates to the nucleus under metabolic stress and regulates gene expression.
Where it has been studied
- Insulin sensitivity models in rodents
- Exercise and metabolic stress studies
- Mitochondrial-nuclear signalling
Selected literature
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceLee C et al. · Cell Metab, 2015 · PMID 25738459
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationZheng Y et al. · Front Endocrinol (Lausanne), 2023 · PMID 36761202
- The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitusYin Y et al. · Pharmacol Res, 2022 · PMID 34798268
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
