SS-31
What it is
SS-31 (elamipretide) is a synthetic aromatic-cationic tetrapeptide that concentrates in the inner mitochondrial membrane, where it binds cardiolipin. It has been studied in clinical trials and is supplied here as a research reagent.
Where it has been studied
- Cardiolipin binding and electron transport chain studies
- Mitochondrial dysfunction models
- Ischaemia-reperfusion research
Selected literature
- Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic PotentialTung C et al. · Int J Mol Sci, 2025 · PMID 39940712
- Mitochondrial protein interaction landscape of SS-31Chavez JD et al. · Proc Natl Acad Sci U S A, 2020 · PMID 32554501
- Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat ModelVahle B et al. · Circ Heart Fail, 2026 · PMID 42290373
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
