ACE-031

What it is

ACE-031 (ACVR2B-Fc) is a recombinant fusion protein that combines the extracellular domain of the activin receptor type IIB with an immunoglobulin Fc region. It binds ligands of the TGF-beta family such as myostatin (GDF-8) and activin A in solution, which is why it is used as a decoy receptor in research.

Where it has been studied

• Myostatin and activin signalling in skeletal muscle models
• Neuromuscular disease models
• Bone and adipose endpoints in preclinical studies

Selected literature

• Gel Electrophoretic Detection of Black Market ACE-031Reichel C et al. · Drug Test Anal, 2025 · PMID 40312924

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.