AICAR
What it is
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide, acadesine) is a small-molecule analogue of AMP. Inside cells it is phosphorylated to ZMP, which activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance.
Where it has been studied
- AMPK signalling in cell culture
- Glucose uptake and mitochondrial biogenesis models
- Exercise-mimetic studies in rodents
Selected literature
- Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating MitophagyChandrasekaran K et al. · Int J Mol Sci, 2024 · PMID 39795939
- AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathwayTsogbadrakh B et al. · Biochem Biophys Res Commun, 2019 · PMID 30616891
- Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old ratsOki K et al. · Appl Physiol Nutr Metab, 2018 · PMID 29518344
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
