IGF-1 LR3
What it is
IGF-1 LR3 is a recombinant 83-amino-acid analogue of IGF-1 with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. The changes reduce binding to IGF-binding proteins, which is why it is used in cell-culture work where sustained IGF-1 receptor activity is wanted.
Where it has been studied
- Cell proliferation and survival assays
- Muscle cell and myotube cultures
- IGF-1 receptor signalling
Selected literature
- Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastorisLu Z et al. · Appl Microbiol Biotechnol, 2023 · PMID 37261455
- Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD miceEngel MG et al. · J Alzheimers Dis, 2025 · PMID 39610283
- Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifersHill RA et al. · Domest Anim Endocrinol, 1999 · PMID 10370861
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
