Kisspeptin-10
What it is
Kisspeptin-10 is the shortest active fragment of the kisspeptin peptides encoded by the KISS1 gene. Acting on the KISS1R receptor, it is a key regulator of GnRH neurons and a reference compound in reproductive neuroendocrinology.
Where it has been studied
- GnRH neuron activation
- Puberty and fertility models
- Metastasis-suppressor (metastin) biology
Selected literature
- Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studiesKe R et al. · Peptides, 2019 · PMID 30339828
- Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of SrcLi Z et al. · Nat Commun, 2024 · PMID 38346942
- Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insightsNetesa MA et al. · In Silico Pharmacol, 2026 · PMID 42707558
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
