Semax

What it is

Semax is a seven-amino-acid peptide derived from the ACTH(4-10) fragment with a Pro-Gly-Pro extension. It originates from Russian neuropeptide research and is studied in nootropic and neuroprotection models.

Where it has been studied

• BDNF expression and neurotrophin signalling
• Ischaemia models
• Attention and memory tasks in rodents

Selected literature

• Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodentsEremin KO et al. · Neurochem Res, 2005 · PMID 16362768
• Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white ratsGlazova NY et al. · Neuropeptides, 2021 · PMID 33418449
• Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stressInozemtseva LS et al. · Eur J Pharmacol, 2024 · PMID 39442746

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.