SLU-PP-332

What it is

SLU-PP-332 is a synthetic small molecule, not a peptide, that activates the oestrogen-related receptors (ERR alpha, beta and gamma), transcription factors involved in mitochondrial biogenesis and oxidative metabolism.

Where it has been studied

• ERR transcriptional activity assays
• Skeletal muscle oxidative capacity in rodents
• Exercise-mimetic studies

Selected literature

• Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise CapacityBillon C et al. · ACS Chem Biol, 2023 · PMID 36988910
• A Synthetic ERR Agonist Alleviates Metabolic SyndromeBillon C et al. · J Pharmacol Exp Ther, 2024 · PMID 37739806
• Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial FunctionXu W et al. · Circulation, 2024 · PMID 37961903

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.