FOXO4-DRI
What it is
FOXO4-DRI (Proxofim) is a cell-permeable peptide built from D-amino acids in reverse sequence order, designed to disrupt the binding of the transcription factor FOXO4 to p53 in senescent cells.
Where it has been studied
- Senolytic mechanisms in cell culture
- Ageing and chemotoxicity models in mice
- FOXO4 and p53 signalling
Selected literature
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human ChondrocytesHuang Y et al. · Front Bioeng Biotechnol, 2021 · PMID 33996787
- FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged miceZhang C et al. · Aging (Albany NY), 2020 · PMID 31959736
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylationKong YX et al. · Commun Biol, 2025 · PMID 39994346
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
