PNC-27
What it is
PNC-27 is a synthetic peptide that combines a segment of the p53 protein with a membrane-residency sequence. It is studied in cancer cell lines for its interaction with membrane-bound HDM-2.
Where it has been studied
- Cancer cell line cytotoxicity assays
- Membrane HDM-2 binding studies
- p53 pathway research
Selected literature
- PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell LysisSarafraz-Yazdi E et al. · Biomedicines, 2022 · PMID 35625682
- Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic CellsThadi A et al. · Anticancer Res, 2020 · PMID 32878773
- HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical CellsKrzesaj PK et al. · Ann Clin Lab Sci, 2025 · PMID 40750238
PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.
