peptide

PNC-27

A membrane-active peptide derived from the p53 and MDM2 binding domain.

PNC-27 · 10 mg · Lyophilised vial

peptide

PNC-27

A membrane-active peptide derived from the p53 and MDM2 binding domain.

€ 150.00per vial, EUR

In stock

Presentation1 option

10 mg · Lyophilised vial€ 150.00

Lyophilised powder in a sealed glass vial

Storage: -20 °C for long-term storage; 2 to 8 °C for under three months; away from light

Tracked shipping EUR 9.95 per order. Benelux 1 to 2 business days, Germany and France 2 to 3, rest of Europe 3 to 5. Details

Batch certificate: not yet published online. Request one for this presentation.

Research use only. Not for human or veterinary use.

What it is

PNC-27 is a synthetic peptide that combines a segment of the p53 protein with a membrane-residency sequence. It is studied in cancer cell lines for its interaction with membrane-bound HDM-2.

Where it has been studied

Cancer cell line cytotoxicity assays
Membrane HDM-2 binding studies
p53 pathway research

Selected literature

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell LysisSarafraz-Yazdi E et al. · Biomedicines, 2022 · PMID 35625682
Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic CellsThadi A et al. · Anticancer Res, 2020 · PMID 32878773
HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical CellsKrzesaj PK et al. · Ann Clin Lab Sci, 2025 · PMID 40750238

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.

Specifications

Compound	PNC-27
Type	Peptide
Selected presentation	10 mg · Lyophilised vial
Form	Lyophilised powder in a sealed glass vial
Fill volume and concentration	Not applicable (lyophilised)
Label	CELVIVE wordmark, compound name, amount, "Purity: >99%", "For research use only"
Storage	-20 °C for long-term storage; 2 to 8 °C for under three months; away from light
Certificate of analysis	Not yet published online. Request for a batch
Research areas	Immune & signalling
All presentations	10 mg lyophilised vial · € 150.00

Handling

Lyophilised peptides tolerate room temperature for several weeks in transit. Move to cold storage on receipt.
Reconstituted vials are typically used within three to four weeks at 2 to 8 °C; stability varies by compound.
Opened or unsealed vials cannot be returned. Transit damage must be documented within 24 hours.

Storage and stability FAQ