peptide · also known as Proxofim

FOXO4-DRI

A D-retro-inverso peptide that targets the FOXO4 and p53 interaction in senescence research.

FOXO4-DRI · 10 mg · Lyophilised vial

peptide · also known as Proxofim

FOXO4-DRI

A D-retro-inverso peptide that targets the FOXO4 and p53 interaction in senescence research.

€ 150.00per vial, EUR

In stock

Presentation1 option

10 mg · Lyophilised vial€ 150.00

Lyophilised powder in a sealed glass vial

Storage: -20 °C for long-term storage; 2 to 8 °C for under three months; away from light

Tracked shipping EUR 9.95 per order. Benelux 1 to 2 business days, Germany and France 2 to 3, rest of Europe 3 to 5. Details

Batch certificate: not yet published online. Request one for this presentation.

Research use only. Not for human or veterinary use.

What it is

FOXO4-DRI (Proxofim) is a cell-permeable peptide built from D-amino acids in reverse sequence order, designed to disrupt the binding of the transcription factor FOXO4 to p53 in senescent cells.

Where it has been studied

Senolytic mechanisms in cell culture
Ageing and chemotoxicity models in mice
FOXO4 and p53 signalling

Selected literature

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human ChondrocytesHuang Y et al. · Front Bioeng Biotechnol, 2021 · PMID 33996787
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged miceZhang C et al. · Aging (Albany NY), 2020 · PMID 31959736
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylationKong YX et al. · Commun Biol, 2025 · PMID 39994346

PubMed records selected for relevance to the compound. They describe published research, not outcomes or uses.

Specifications

Compound	FOXO4-DRI (Proxofim)
Type	Peptide
Selected presentation	10 mg · Lyophilised vial
Form	Lyophilised powder in a sealed glass vial
Fill volume and concentration	Not applicable (lyophilised)
Label	CELVIVE wordmark, compound name, amount, "Purity: >99%", "For research use only"
Storage	-20 °C for long-term storage; 2 to 8 °C for under three months; away from light
Certificate of analysis	Not yet published online. Request for a batch
Research areas	Longevity & mitochondrial
All presentations	10 mg lyophilised vial · € 150.00

Handling

Lyophilised peptides tolerate room temperature for several weeks in transit. Move to cold storage on receipt.
Reconstituted vials are typically used within three to four weeks at 2 to 8 °C; stability varies by compound.
Opened or unsealed vials cannot be returned. Transit damage must be documented within 24 hours.

Storage and stability FAQ