FOXO4-DRI
A synthetic cell-permeable antagonist peptide designed to study senescent cell apoptosis and cellular rejuvenation pathways.
FOXO4-DRI (FOXO4 D-Retro-Inverso) is a high-performance research peptide created to disrupt the crucial interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein. In cellular biology, senescent cells frequently utilize this pathway to evade apoptosis. Researchers investigate FOXO4-DRI for its targeted senolytic properties, selectively forcing senescent cells into apoptosis while leaving healthy, dividing cells unaffected.
Scientific Reference Library
Research: Targeted apoptosis of senescent cells by a FOXO4-p53 disrupting peptide
Link: https://pubmed.ncbi.nlm.nih.gov/28334815/
Research: The impact of FOXO4-DRI on the expression of Senescence-Associated Secretory Phenotype (SASP)
€ 150.00
